OverviewDiscovering the molecular basis of observed genetic contributions to complex disease has proven to be difficult in all but a few cases. This is because most complex diseases are likely caused by interactions between many genes, and the effect of any one variation does not fully account for the disease. To date most genetic discovery technologies have been limited to the study of small numbers of the most common single nucleotide polymorphisms (SNPs) discovered from large-scale sequencing studies.
ParAllele has developed a suite of high-throughput tools that allow for the comprehensive study of genetic material. ParAllele uses two core technologies, Molecular Inversion Probe (MIP) technology and Mismatch Repair Detection (MRD), along with ParAllele TrueTag technology, for highly multiplexed assays to perform variation discovery and SNP genotyping. Each of these assays allows tens of thousands of SNPs or genes to be analyzed in a single laboratory reaction, greatly reducing the cost and complexity of comprehensive genetic studies.
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