MegAllele" Genotyping Services

Researchers in academia and industry can now easily access the same MegAllele genotyping platform that has been utilized in the international HapMap program and by leading pharmaceutical companies. The MegAllele line of genotyping services provides the quickest, most reliable and most cost-effective way for researchers to carry out large scale disease association and linkage fine mapping studies. ParAllele can provide researchers with complete solutions including assistance in study design, SNP discovery, assay development, genotyping, and downstream genetic analysis.

The MegAllele System Is Available in ParAllele BioScience Services Now

Parallele is offering SNP genotyping services using the innovative MegAllele technology. The MegAllele System is for application-specific and custom genotyping and is a highly multiplexed assay based on Molecular Inversion Probe Technology. It enables the highest level of multiplexing that is commercially available. Choose from a growing menu of application-specific fixed assay products (including our newest product a panel consisting of 10K non-synonymous SNPs) and custom designed panels that also have the highest conversion rates available.

Key Specifications:

• Conversion Rate: ≥ 80% (custom panels)
• Accuracy: ≥ 99.5% (custom and application-specific panels)
• Data Completeness:  ≥ 98.0% (application-specific panels) ≥ 97.0% (custom panels)
• Reproducibility: ≥ 99.5%
• Quantity of Genomic DNA required without amplification: 2.0 µg for 3K to 5K SNPs and 4.0 µg for 6K to 10K SNPs
• Quantity of genomic DNA required with recommended amplification protocol is less than 50 ng (download protocol)

MegAllele Services Overview

Application Specific Panels available include

MegAllele Genotyping Human 10K cSNP Panel I:

• Contains 10,000 amino acid-changing SNPs that are multiplexed in a single assay. The panel includes SNPs chosen to represent more than 8,000 genes that have validated (double-hit) non-synonymous public SNPs that code for functional changes.
• MegAllele Genotyping Mouse 5K SNP Panel
• Contains approximately 5,000 SNPs in a highly multiplexed assay. It allows individual researchers to perform high resolution linkage mapping studies on mouse strains, resulting in approximately 1,500 informative markers for every cross of twenty common strains.

Also offered are Custom Panels service available in 3K, 5K and 10K SNP configurations.

Work Service Flow Chart

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For information on how to obtain MegAllele genotyping services in your lab:
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